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. 2022 Sep 21;13:5538. doi: 10.1038/s41467-022-33162-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Experimental design and timeline (created with BioRender.com). UpSet plots of the overlaps of gene mappings from pairwise DMR comparisons of b obese vs. control for cffDNA from trimester 1 (n_obese = 7, n_control = 4), trimester 2 (n_obese = 7, n_control = 4), early trimester 3 (n_obese = 7, n_control = 5), and late trimester 3 (n_obese = 7, n_control = 6) as well as infant brain (n_obese = 7, n_control = 6 for hippocampus, hypothalamus, and prefrontal cortex), c caloric restriction vs. obese for cffDNA from trimester 1 (n_{caloric restriction} = 4, n_obese = 7), trimester 2 (n_{caloric restriction} = 5, n_obese = 7), early trimester 3 (n_{caloric restriction} = 5, n_obese = 7), and late trimester 3 (n_{caloric restriction} = 7, n_obese = 5) as well as infant brain (n_{caloric restriction} = 5, n_obese = 7 for hippocampus, hypothalamus, and prefrontal cortex), and d pravastatin vs. obese for cffDNA from trimester 1 (n_pravastatin = 7, n_obese = 7), trimester 2 (n_pravastatin = 7, n_obese = 7), early trimester 3 (n_pravastatin = 7, n_obese = 7), and late trimester 3 (n_pravastatin = 7, n_obese = 7) as well as infant brain (n_pravastatin = 7, n_obese = 7 for hippocampus, hypothalamus, and prefrontal cortex). Source data are provided as a Source Data file.