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. 2022 Sep 21;13:5538. doi: 10.1038/s41467-022-33162-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Top slimmed gene ontology (GO) enrichment testing results for the a cffDNA and b brain consensus DMRs. Top PANTHER pathway enrichments for the c cffDNA, and d brain consensus DMRs. Top human methylation-sensitive transcription factor motif enrichment testing results for the e cffDNA and f brain consensus DMRs. The motif names indicate whether the transcription factor was full-length (“-FL”) or an extended DNA-binding domain (“-eDBD”), if the CpGs were methylated (“-methyl”); and the number (starting with “−1”) distinguishes between multiple motifs. Source data are provided as a Source Data file.