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. 2022 Sep 21;3:29. doi: 10.1186/s43556-022-00090-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Syt1 and its interactions with SNARE complex and membrane. a Domain diagram of Syt1. Residue numbers are indicated below the diagram. b Crystal structure of the primary interface of SNARE-Syt1 complex in Rattus norvegicus (PDB ID: 5CCI) [240]. c Crystal structure of the tripartite interface of SNARE-Syt1-Cpx1 complex in Rattus norvegicus (PDB ID: 5W5D) [241]. d Model of polybasic region of C2B domain interacting with the anionic membrane (PDB ID: 1K5W) [242]. The side chains of the residues in the polybasic region (K313, K321, R322, K324, K326, K325 and K327) are shown in blue sticks. e Crystal structure of the tandem Syt1 C2AB (orange) domains in Rattus norvegicus (PDB ID: 5KJ7) [239] in the presence of Ca²⁺ (cyan sphere)