Table 2.
Classic proteins involve in different vesicle transport pathways
| Transport pathways | Rab GTPases | Motor adaptor | Motor protein | Cytoskeleton | Tethering protein |
|---|---|---|---|---|---|
| ER to Golgi transport | Rab1 | Sec23 | Dynein-dynactin complex, KIF5B | Microtubule | TRAPPI, p115, GM130 |
| Retrograde transport from the Golgi to the ER | Rab6A | BicaudalD |
COPI-dependent: Rabkinesin-6, KIF1C COPI-independent: Dynein-dynactin complex |
COPI-dependent: Microtubule COPI-independent: Microtubule |
COPI-dependent: Dsl1, COG, CASP |
| Transport from TGN to plasma membrane |
Endocrine secretion: Rab3 Exocrine secretion: Rab27, Rab3D |
Endocrine secretion: DENN/MADD Exocrine secretion: MyRIP |
Endocrine secretion: KIF1A Exocrine secretion: Myosin V |
Endocrine secretion: Microtubule Exocrine secretion: Actin |
Endocrine secretion: Exocyst, RIM Exocrine secretion: Exocyst |
| Transport from TGN to endosome | Rab14 | / | KIF16B | Microtubule | CORVET |
| Transport from endosomes to TGN | Rab6 | SNX6 | Dynein-dynactin complex | Microtubule | GARP, COG |
| Transport from plasma membrane to early endosome | Rab5 | Dab2 | Myosin VI | Actin | EEA1 |
| Transport from recycling endosome to plasma membrane | Rab11 | FIP2 | Myosin Vb | Actin | Exocyst |
| Transport from endosome to late endosome | Rab5 | HOOK | Dynein-dynactin complex | Microtubule | / |
| Transport from endosome to lysosome | Rab7 | RILP | Dynein-dynactin complex | Microtubule | HOPS |
| Transport from autophagosome to lysosome | Rab7 |
FYCO1 LC3 |
Kinesin-1 | Microtubule | EPG5, HOPS, ATG14, PLEKHM1 |