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. 2022 Sep 8;13:976011. doi: 10.3389/fimmu.2022.976011

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Copyright © 2022 Mispelbaum, Hattenhauer, Brossart and Heine

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IrAE and infection rate in relation to RBC transfusions. (A) The irAE rate depending on received RBC transfusions within 60 days after start of IT is shown. Of 40 patients in the non-transfused group 6 patients (15.0%) showed an irAE while of 15 patients in the transfused group 5 patients (33.3%) showed an irAE. The difference was calculated using Fisher’s exact test (p=0.149). (B) The infection rate depending on received RBC transfusions within 30 days before start of IT is shown. Of 46 patients in the non-transfused group 13 patients (28.3%) were treated with antibiotic treatment, while of 9 patients in the transfused group 5 patients (55.6%). The difference was calculated using Fisher’s exact test (p=0.135). RBC, red blood cell; irAE, immune-related adverse events; NS, not significant.