Table 1.

Host innate immunity against DENV and ZIKV.

Virus	Virus factor	IFN Pathway	Host target	References
DENV	NS2A and NS4B	RLR, TLR, cGAS-STING	Reduction of IRF3 protein production and inhibition of TBKI	(Dalrymple et al., 2015)
ZIKV	NS5	RLR, TLR, cGAS-STING	IRF3 binding	(Kumar et al., 2016; Xia et al., 2018)