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. 2022 Sep 8;13:986303. doi: 10.3389/fendo.2022.986303

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Copyright © 2022 Wang, Tang, Jin, Ren, Li, Zhang, Zhong, Cao, Wang, Zhou, Zhao, Huang and Qu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OPLS-DA model and PCA model. The four groups were well separated in the OPLS-DA score plot (R2X = 0.881, R2Y = 0.786 and Q2 = 0.264.) The PCA model for samples collected from 4 isolates of sample data. Green dot: control. Blue dot: T2DM sample. Red dot: NPDR sample. Yellow dot: PDR sample. OPLS-DA, orthogonal partial least squares- discriminant analysis; PCA, principal component analysis; T2DM, type 2 diabetes mellitus; NPDR, non-proliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy.