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. 2022 Sep 8;13:986303. doi: 10.3389/fendo.2022.986303

Table 3.

Validate the Differential Metabolites in control, T2DM, NPDR, PDR and DR groups by ELISA.

L-Citrulline(pg/ml) Indoleacetic Acid(ng/ml) Chenodeoxycholic Acid (nmol/L) Eicosapentaenoic Acid (pg/ml)
Subjects, n 18 18 18 18
Control 286.68 ± 85.17 70.47 ± 23.80 1651.27 ± 577.20 312.45 ± 47.91
T2DM 500.11 ± 276.85 53.33 ± 16.66 2650.36 ± 469.08 263.19 ± 38.20
NPDR 180.52 ± 110.30 83.48 ± 20.29 2022.46 ± 710.91 256.05 ± 27.69
PDR 169.37 ± 141.23 93.16 ± 37.28  826.51 ± 667.37 196.51 ± 22.55
DR 174.94 ± 126.83 88.32 ± 30.40 1426.30 ± 888.79 226.28 ± 39.03
P-value < 0.001 < 0.001 < 0.001 < 0.001
 Pa 0.001 0.359 0.001 0.001
 Pb 0.284 0.633 0.570 < 0.001
 Pc 0.193 0.116 0.013 < 0.001
 Pd 0.122 0.185 0.830 < 0.001
 Pe < 0.001 0.014 0.093 0.979
 Pf < 0.001 < 0.001 < 0.001 0.008
 Pg < 0.001 < 0.001 < 0.001 < 0.001
 Ph > 0.999 0.838 < 0.001 < 0.001
 Pi > 0.999 0.975 0.050 0.054
 Pj > 0.999 0.975 0.061 0.054

T2DM, type 2 diabetes mellitus; NPDR, non-proliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy; DR, diabetic retinopathy. Pa, P-value of control subjects versus T2DM samples. Pb, P-value of control subjects versus NPDR samples. Pc, P-value of control subjects versus PDR samples. Pd, P-value of control subjects versus DR samples. Pe, P-value of T2DM samples versus NPDR samples. Pf, P-value of T2DM samples versus PDR samples. Pg, P-value of T2DM samples versus DR samples. Ph, P-value of NPDR samples versus PDR samples. Pi, P-value of NPDR samples versus DR samples. Pj, P-value of PDR samples versus DR samples.