Table 3.

Multiplicative interaction between SNPs of the MTHFR gene and maternal folic acid use detected by logistic regression.

MTHFR genotype	Maternal folic acid use
	Adjusted OR (95%CI)†	P	FDR-P
rs2274976	1.13 (0.89–1.43)	0.334	0.638
rs4846052	1.06 (0.84–1.34)	0.603	0.849
rs1476413	1.32 (1.07–1.63)	0.010	0.093
rs2066470	1.36 (1.07–1.73)	0.013	0.016
rs1801133	1.28 (1.08–1.62)	0.011	0.003
rs1801131	1.59 (1.28–1.98)	0.000	0.000

SNP, single nucleotide polymorphism; MTHFR, Methylenetetrahydrofolate reductase; CI, confidence interval; OR, odds ratio; FDR, false discovery rate.

^†Adjusted for gender, maternal age at pregnancy onset, education status, residence location, adverse pregnancy history (induced abortion or labor, fetal death or stillbirth, neonatal death, hypertension of pregnancy, gestational diabetes mellitus), family history (consanguineous marriages), maternal lifestyle before this pregnancy, harmful chemicals' exposure history in this pregnancy.

Bold font indicates statistical significant.