Table 3.
Logistic regression analysis of factors associated with grade 4 lymphopenia.
| OR | 95% CI | P | |
|---|---|---|---|
| Age | 1.026 | 0.942–1.118 | 0.552 |
| Male vs. Female | 1.286 | 0.255–6.492 | 0.761 |
| TM Dmean | 1.176 | 1.084–1.275 | <0.001 |
| TVB Dmean | 1.159 | 1.078–1.246 | <0.001 |
| Sternum Dmean | 1.109 | 1.001–1.228 | 0.048 |
| TM V5 | 1.091 | 1.040–1.144 | <0.001 |
| TVB V5 | 1.075 | 1.034–1.118 | <0.001 |
| Sternum V5 | 2.421 | 0.576–10.189 | 0.228 |
| TM V10 | 1.087 | 1.039–1.137 | <0.001 |
| TVB V10 | 1.073 | 1.034–1.114 | <0.001 |
| Sternum V10 | 1.225 | 1.040–1.443 | 0.015 |
| TM V20 | 1.083 | 1.040–1.127 | <0.001 |
| TVB V20 | 1.074 | 1.036–1.113 | <0.001 |
| Sternum V20 | 1.045 | 1.004–1.088 | 0.032 |
| TM V30 | 1.063 | 1.030–1.097 | <0.001 |
| TVB V30 | 1.061 | 1.031–1.091 | <0.001 |
| Sternum V30 | 0.979 | 0.940–1.020 | 0.307 |
| TM V40 | 1.057 | 1.019–1.096 | 0.003 |
| TVB V40 | 1.057 | 1.023–1.092 | 0.001 |
| Sternum V40 | 0.995 | 0.957–1.036 | 0.815 |
| TM V50 | 1.100 | 1.018–1.189 | 0.016 |
| TVB V50 | 1.091 | 1.018–1.170 | 0.014 |
| Sternum V50 | 1.037 | 0.959–1.123 | 0.363 |
| Heart Dmean | 1.152 | 1.062–1.251 | 0.001 |
| Heart V15 | 1.056 | 1.024–1.090 | 0.001 |
| Heart V20 | 1.050 | 1.023–1.078 | <0.001 |
| Heart V30 | 1.083 | 1.036–1.133 | <0.001 |
| Heart V40 | 1.122 | 1.049–1.201 | 0.001 |
| Heart V50 | 1.269 | 1.112–1.449 | <0.001 |
| PTV Volume | 1.006 | 1.002–1.011 | 0.009 |
| PTV Dmean | 1.566 | 1.170–2.095 | 0.003 |
| IMRT vs. VMAT | 0.544 | 0.164–1.808 | 0.320 |
OR, odd ratio; CI, confidence interval; TM, thoracic marrow; TVB, thoracic vertebral body; PTV, planning target volume; Dmean, mean dose; Vx, relative volume of receiving x Gy.