Table 4.
Members of the miR-200 family regulating cancer cell migration and invasion.
| miRNAs | Cancer | Target | Cell migration in vitro | Cell invasion in vitro | Ref. |
|---|---|---|---|---|---|
| miR-200a | Acute myeloid leukemia | n/d | n/d | n/d | n/d |
| Acute lymphoblastic leukemia | n/d | n/d | n/d | n/d | |
| Bladder cancer | DICER | n/d | ↑ | (41) | |
| Breast cancer | ELK3, EPHA2 | ↓ | ↓ | (315, 316) | |
| Cervical cancer | n/d | n/d | n/d | n/d | |
| Cholangiocarcinoma | n/d | n/d | ↓ | (52) | |
| Colorectal cancer | FOXA1 | ↓ | ↓ | (221, 222) | |
| Endometrial cancer | n/d | n/d | n/d | n/d | |
| Esophageal carcinoma | CTNNB1, CDH1, APC, PTEN, CTNNA1 and SOD2 | ↑ | ↑ | (70) | |
| Gastric cancer | n/d | ↓ | ↓ | (225) | |
| Glioma | FOXA1, SIM2-s | ↓ | ↓ | (83, 226) | |
| Head and neck carcinoma | CD47 | ↓ | ↓ | (86) | |
| Liver cancer | STAT4, Foxa2 | ↓ | ↓ | (161, 162, 227) | |
| Melanoma | GOLM1 | ↓ | ↓ | (228) | |
| Nephroblastoma | n/d | n/d | n/d | n/d | |
| Neuroblastoma | n/d | n/d | n/d | n/d | |
| Non-small cell lung cancer | HGF | ↓ | ↓ | (100) | |
| Oral squamous cell carcinoma | n/d | n/d | n/d | n/d | |
| Osteosarcoma | ZEB1 | ↓ | n/d | (104) | |
| Ovarian cancer | PDCH9 | ↑ | ↑ | (111, 113) | |
| Pancreatic cancer | DEK | ↓ | ↓ | (231, 232, 317) | |
| Prostate cancer | n/d | n/d | ↓ | (233) | |
| Renal cell carcinoma | TGFβ2 | ↓ | ↓ | (235) | |
| Small cell lung carcinoma | n/d | n/d | n/d | n/d | |
| Thyroid cancer | FOXA1 | ↓ | ↓ | (130) | |
| miR-200b | Acute myeloid leukemia | n/d | n/d | ↓ | (237) |
| Acute lymphoblastic leukemia | n/d | n/d | n/d | n/d | |
| Bladder cancer | FSCN1 | ↓ | ↓ | (238) | |
| Breast cancer | IKBKB, FUT4, PKCα, radixin, | ↓ | ↓ | (240–242, 318, 319) | |
| Cervical cancer | FoxG1, RhoE | ↓/↑ | ↓/↑ | (45, 243, 320) | |
| Cholangiocarcinoma | SUZ12 and ROCK2 | ↓ | ↓ | (51) | |
| Colorectal cancer | TUBB3 | ↓ | ↓ | (247) | |
| Endometrial cancer | TIMP2 | ↓ | n/d | (321) | |
| Esophageal carcinoma | Kindlin-2 | ↓ | ↓ | (322) | |
| Gastric cancer | ZEB2 | ↓ | ↓ | (248) | |
| Glioma | CD133, ERK5 | ↓ | ↓ | (250, 251) | |
| Head and neck carcinoma | Notch1 | ↓ | ↓ | (252) | |
| Liver cancer | HMGB3 | ↓ | n/d | (90) | |
| Melanoma | n/d | ↓ | ↓ | (253) | |
| Nephroblastoma | IKK-β | ↓ | ↓ | (98) | |
| Neuroblastoma | n/d | n/d | n/d | n/d | |
| Non-small cell lung cancer | ABCA1, p70S6K1, RhoE, TIF1γ | ↑/↓ | ↑/↓ | (255, 256, 323, 324) | |
| Oral squamous cell carcinoma | Kindlin-2, ZEB2 | ↓ | ↓ | (257) | |
| Osteosarcoma | ZEB1 | ↓ | ↓ | ||
| Ovarian cancer | n/d | n/d | n/d | n/d | |
| Pancreatic cancer | n/d | n/d | n/d | n/d | |
| Prostate cancer | n/d | ↓ | ↓ | (233, 261, 262) | |
| Renal cell carcinoma | n/d | ↑ | n/d | (124) | |
| Small cell lung carcinoma | n/d | n/d | n/d | n/d | |
| Thyroid cancer | RAP1B | ↓ | ↓ | (132, 325) | |
| miR-200c | Acute myeloid leukemia | n/d | n/d | n/d | n/d |
| Acute lymphoblastic leukemia | n/d | n/d | n/d | n/d | |
| Bladder cancer | BMI-1, E2F3, LDHA, RECK | ↑/↓ | ↑/↓ | (36, 38, 263) | |
| Breast cancer | n/d | ↓ | ↓ | (267, 268, 326) | |
| Cervical cancer | MAP4K4 | ↓ | n/d | (270) | |
| Cholangiocarcinoma | SUZ12 and ROCK2 | ↓ | ↓ | (51) | |
| Colorectal cancer | n/d | ↓ | ↓ | (327) | |
| Endometrial cancer | PTEN, PTENP1 | ↑/↓ | ↑/↓ | (272, 328; 273) | |
| Esophageal carcinoma | n/d | n/d | n/d | n/d | |
| Gastric cancer | EDNRA, FN1 | ↓ | ↓ | (274, 275) | |
| Glioma | MSN | ↓ | ↓ | (79) | |
| Head and neck carcinoma | PTEN | ↑ | ↑ | (276) | |
| Liver cancer | MAD2L1 | ↓ | ↓ | (88) | |
| Melanoma | n/d | ↓ | n/d | (277) | |
| Nephroblastoma | FRS2, IKK-β | ↓ | ↓ | (97, 98) | |
| Neuroblastoma | n/d | n/d | n/d | n/d | |
| Non-small cell lung cancer | LDHA | ↓ | n/d | (280) | |
| Oral squamous cell carcinoma | ZEB1 | ↓ | ↓ | (329) | |
| Osteosarcoma | AKT2 | ↓ | n/d | (105) | |
| Ovarian cancer | n/d | ↓ | ↓ | (281, 282) | |
| Pancreatic cancer | n/d | n/d | ↓ | (283, 330) | |
| Prostate cancer | AMACR, ZEB2 | ↓ | ↓ | (122, 284, 285) | |
| Renal cell carcinoma | SLC6A1 | ↑/↓ | ↓ | (124, 128) | |
| Small cell lung carcinoma | n/d | n/d | n/d | n/d | |
| Thyroid cancer | RAP1B | ↓ | ↓ | (132) | |
| miR-141 | Acute myeloid leukemia | n/d | n/d | n/d | n/d |
| Acute lymphoblastic leukemia | n/d | n/d | n/d | n/d | |
| Bladder cancer | n/d | n/d | n/d | n/d | |
| Breast cancer | ANP32E, ZEB1/2 | ↓ | ↓ | (287, 331) | |
| Cervical cancer | FOXA2 | n/d | ↑ | (289) | |
| Cholangiocarcinoma | n/d | n/d | n/d | n/d | |
| Colorectal cancer | EGFR | ↓ | ↓ | (332) | |
| Endometrial cancer | n/d | n/d | n/d | n/d | |
| Esophageal carcinoma | n/d | ↓ | ↓ | (67) | |
| Gastric cancer | TAZ | ↓ | ↓ | (292) | |
| Glioma | SKA2 | ↓ | ↓ | (77) | |
| Head and neck carcinoma | EGFR | ↓ | ↓ | (85) | |
| Liver cancer | TGFβR1 | ↓ | ↓ | (91) | |
| Melanoma | n/d | n/d | n/d | n/d | |
| Nephroblastoma | n/d | n/d | n/d | n/d | |
| Neuroblastoma | FUS | ↓ | ↓ | (293) | |
| Non-small cell lung cancer | KLF9 | n/d | ↑ | (295) | |
| Oral squamous cell carcinoma | n/d | n/d | n/d | n/d | |
| Osteosarcoma | FUS | ↓ | ↓ | (296) | |
| Ovarian cancer | n/d | ↓ | ↓ | (297) | |
| Pancreatic cancer | MAP4K4, TM4SF1 | ↓ | ↓ | (298, 333) | |
| Prostate cancer | RUNX1 | ↓ | ↓ | (300) | |
| Renal cell carcinoma | n/d | ↑ | n/d | (124) | |
| Small cell lung carcinoma | n/d | n/d | n/d | n/d | |
| Thyroid cancer | IRS2 | ↓ | ↓ | (129) | |
| miR-429 | Acute myeloid leukemia | n/d | n/d | n/d | n/d |
| Acute lymphoblastic leukemia | n/d | n/d | n/d | n/d | |
| Bladder cancer | n/d | ↓ | ↓ | (334) | |
| Breast cancer | FN1 | ↓ | ↓ | (301) | |
| Cervical cancer | ZEB1 | ↓ | ↓ | (302) | |
| Cholangiocarcinoma | n/d | n/d | n/d | n/d | |
| Colorectal cancer | Onecut2, PAK6 | ↓ | ↓ | (55, 335) | |
| Endometrial cancer | n/d | n/d | n/d | n/d | |
| Esophageal carcinoma | Bcl-2, Slug, SP1 | ↓ | ↓ | (65, 68) | |
| Gastric cancer | Sp1, Notch1 | ↓ | ↓ | (336, 337) | |
| Glioma | BMK1, SOX2 | ↓ | ↓ | (82, 338) | |
| Head and neck carcinoma | n/d | ↓ | ↓ | (304) | |
| Liver cancer | CRKL, RAB23 | ↓ | ↓ | (89, 305) | |
| Melanoma | LIMK1 | ↓ | ↓ | (94) | |
| Nephroblastoma | IKK-β | ↓ | ↓ | (98) | |
| Neuroblastoma | IKKβ | ↓ | ↓ | (307) | |
| Non-small cell lung cancer | PTEN, RASSF8, TIF1γ and TIMP2, | ↑ | ↑ | (308, 323) | |
| Oral squamous cell carcinoma | n/d | n/d | n/d | n/d | |
| Osteosarcoma | ZEB1, HOXA9 | ↓ | ↓ | (103, 107) | |
| Ovarian cancer | p15PAF | ↓ | n/d | (339) | |
| Pancreatic cancer | NT-3 | n/d | ↓ | (117) | |
| Prostate cancer | n/d | n/d | n/d | n/d | |
| Renal cell carcinoma | n/d | ↑ | n/d | (124) | |
| Small cell lung carcinoma | n/d | n/d | n/d | n/d | |
| Thyroid cancer | ZEB1 | ↓ | ↓ | (131) |
↓ - suppression by miRNA; ↑ - promotion by miRNA; n/d – no data.