Table 7.
Regulation of drug resistance by miR-200 family members.
| miRNAs | Cancer | Target | Drug resistance | Ref. |
|---|---|---|---|---|
| miR-200a | Breast cancer | TP53INP1 | ↑ | (360) |
| Glioma | n/d | ↓ | (81) | |
| Liver cancer | DUSP6 | ↑ | (361) | |
| miR-200b | Bladder cancer | n/d | ↓ | (134) |
| Cholangiocarcinoma | SUZ12 and ROCK2 | ↓ | (51) | |
| Colorectal cancer | TUBB3 | ↓ | (247) | |
| Non-small cell lung cancer | ATG12, E2F3, p70S6K1, SUZ12 | ↓ | (254, 256, 362–365) | |
| Prostate cancer | n/d | ↓ | (262) | |
| Small cell lung cancer | ZEB2 | ↓ | (366) | |
| Ovarian cancer | DNMT3A/DNMT3B | ↓ | (367) | |
| miR-200c | Breast cancer | ↓ | (368) | |
| Gastric carcinoma | ZEB2 | ↓ | (369) | |
| Melanoma | n/d | ↓ | (277) | |
| Osteosarcoma | AKT2 | ↓ | (105) | |
| Ovarian cancer | DNMT3A/DNMT3B | ↓ | (367) | |
| Pancreatic cancer | n/d | ↓ | (330) | |
| Cholangiocarcinoma | SUZ12 and ROCK2 | ↓ | (51) | |
| Esophageal carcinoma | n/d | ↑ | (370) | |
| miR-141 | Colorectal cancer | EGFR | ↓ | (291) |
| Breast cancer | EIF4E | ↑ | (371) | |
| Glioma | TP53 | ↑ | (372) | |
| Neuroblastoma | FUS | ↓ | (293) | |
| Non-small cell lung cancer | PDCD4 | ↑/↓ | (365, 373) | |
| Ovarian cancer | KEAP1 | ↑/↓ | (374, 375) | |
| Pancreatic cancer | MAP4K4 | ↓ | (298) | |
| miR-429 | Colorectal cancer | DUSP4 | ↓ | (376) |
| Endometrial cancer | n/d | ↑ | (60) | |
| Ovarian cancer | ZEB1 | ↓ | (377) |
↓ - suppression by miRNA; ↑ - promotion by miRNA; n/d – no data.