Table 1.
Participant characteristics by vaccination status.
| Overall | COVID-Negative (n=1416) | COVID-Positive (n=96) | |||||
|---|---|---|---|---|---|---|---|
| Participant’s characteristics | N=1510 (%) | Vaccinated, n =1240 (88%) | Unvaccinated, n =176 (12%) | P-value (Vacc vrs unvacc) | Positive COVID-19, N=94 (6%) | P-value(Unvaccinated vs. COVID-19 +) | |
| Age [mean (SD)] | 39 (10) | 39 (11) | 39 (10) | 0.544 | 39 (10) | 0.935 | |
| Sex (at birth) | |||||||
| Male, n (%) | 812 (54) | 677 (55) | 90 (51) | 48 (51) | 0.731 | ||
| Female, n (%) | 640 (42) | 515 (42) | 84 (48) | 0.257 | 41 (44) | 0.731 | |
| Prefer not to answer, n (%) | 58 (4.0) | 48 (4.0) | 2.0 (1.0) | 5.0 (5.0) | |||
| Educational level | |||||||
| Non-university certificate/diploma | 955 (63) | 760 (61) | 131 (74) | 64 (68) | |||
| University bachelor’s degree | 445 (30) | 382 (31) | 40 (23) | 23 (25) | |||
| Masters or Doctorate | 45 (3.0) | 42 (3.0) | 2.0 (1.0) | 0.019 | 1.0 (1.0) | 0.962 | |
| Others | 65 (4.0) | 56 (5.0) | 3.0 (2.0) | 6.0 (6.0) | |||
| January 1 to blood collection date [median (IQR)] | 102 (62, 147) | 104 (63, 152) | 87 (56, 117) | 0.000 | 107 (63, 154) | 0.045 | |
| Vaccination type | |||||||
| BNT162b2 | 1042 (69) | 986 (80) | n/a | n/a | 56(81) | n/a | |
| mRNA-1273 | 235 (16) | 226 (18) | n/a | n/a | 9.0 (13) | n/a | |
| Others | 1.0 (0.0) | 1.0 (1.4) | n/a | ||||
| Did not answer | 31 (2.0) | 28 (2.0) | n/a | n/a | 3.0 (4.3) | n/a | |
| Vaccine Doses | |||||||
| 1st & 2nd Doses (BNT162b2) | 894 (59) | 842 (68) | n/a | n/a | 52 (55) | n/a | |
| 1st & 2nd Doses (mRNA-1273) | 187 (12) | 179 (14) | n/a | n/a | 8.0 (8.5) | n/a | |
| Only one vaccine (BNT162b2) | 134 (8.9) | 131 (11) | n/a | n/a | 3.0 (3.19) | n/a | |
| Only one vaccine (mRNA-1273) | 37 (2.5) | 37 (3.0) | n/a | n/a | 0.0 (0.0) | n/a | |
| Others | 1.0 (0.1) | 0.0 (0.0) | n/a | 0.0 (0.0) | n/a | ||
| 1st vaccine to blood collection date [median (IQR)] | 84 (47, 124) | 84 (47, 125) | n/a | n/a | 90 (54, 111) | n/a | |
| 2nd Vaccine to blood collection [median (IQR)] | 65 (34, 108) | 65 (34, 108) | n/a | n/a | 64 (35, 89) | n/a | |
|
Endemic coronaviruses
[gMean (gSD)] | |||||||
| HCoV-229E Spike | 19699 (2.0) | 19351 (2.0) | 21249 (2.0) | 0.687 | 21647 (2.0) | 0.800 | |
| HCoV-HKU1 Spike | 11963(3.0) | 12488 (3.0) | 8420 (3.0) | 0.000 | 13130 (3.0) | 0.001 | |
| HCoV-NL63 Spike | 3843 (3.0) | 3892 (3.0) | 3613 (2.0) | 0.573 | 3644 (2.0) | 0.598 | |
| HCoV-OC43 Spike | 40142 (2.0) | 41274 (2.0) | 27885 (2.0) | 0.000 | 55270 (2.0) | 0.000 | |
|
SARS-CoV-2 antibodies
[gMean (gSD)] | |||||||
| MSD SARS-CoV-2 N | 204 (5.0) | 172 (4.0) | 139 (4.0) | 0.260 | 4045 (10) | 0.000 | |
| MSD SARS-CoV-2 NTD | 279 (14.0) | 486 (9.0) | 4 (4.0) | 0.000 | 577 (10) | 0.000 | |
| MSD SARS-CoV-2 RBD | 12027 (12) | 20139 (8.0) | 257 (4.0) | 0.000 | 18366 (10) | 0.000 | |
| MSD SARS-CoV-2 Spike | 15577 (18) | 29822 (10) | 96 (5.0) | 0.000 | 31815 (10) | 0.000 | |
gMean, geometric mean; gSD, geometric standard deviation; SD, Standard deviation; IQR, interquartile range; n/a, not applicable.