Table 3.
Hematological and immunological parameters at the time of T. marneffei infection in the six patients.
| P1 | P2 | P3 | P4 | P5 | P6 | |
|---|---|---|---|---|---|---|
| WBC (´109/L) | 10.92 | 10.02 | 33↑ | 27↑ | 3.9↓ | 6.9 |
| ANC (´109/L) | 7.73↑ | 1.74 | 24.72↑ | 13.15↑ | 1.94↓ | 4.38 |
| ALC (´109/L) | 2.09↓ | 7.06 | 5.5 | 10.29↑ | 1.60↓ | 1.70↓ |
| PLT (´109/L) | 188 | 402↑ | 680↑ | 662↑ | 40↓ | 353 |
| Hb (g/L) | 57↓ | 114 | 91↓ | 101↓ | 51↓ | 97↓ |
| CRP (mg/L) | 79↑ | <8 | 79.8↑ | 8.7 | 20↑ | 46↑ |
| ESR (mm/h) | 125↑ | 2 | 120↑ | NA | 2 | 68↑ |
| Ferritin (ng/mL) | 256.6↑ | 60.5 | 51.3 | NA | 928.4↑ | 227↑ |
| ALT (U/L) | 6.22 | 17.1 | 16.2 | 21 | 26.1 | 45.9 |
| AST (U/L) | 18.5 | 42.5 | 28.6 | 38 | 136.9↑ | 63.1↑ |
| G test (pg/mL) | 271.89 ↑ | <37.5 | 17.5 | NA | 1817.7 ↑ | NA |
| GM test (blood/BALF) | 6.682 ↑/NA | 1.497 ↑/0.087 | NA/0.120 | NA/NA | 6.192 ↑/NA | 7.899↑/0.336 |
| CD19 (cells/ul) | 323.1 (18.60%) | 1659.7 (27.54%)↑ | 439.7 (10.35%)↓ | 1734.9 (20.03%) | 1304.6 (52.61%)↑ | 294.20 (15.95%) |
| Naive B (%) | 84.02 | NA | NA | 89.62↑ | 96.30 ↑ | 97.7 ↑ |
| Memory B (%) | 7.89 | NA | NA | 2.76↓ | 0.10 ↓ | 0.2 ↓ |
| Transitional B (%) | 0.44↓ | NA | NA | 2.73↓ | 10.20 | 2.5↓ |
| Plasmablasts (%) | 0.41↓ | NA | NA | 0.29↓ | 0.20 ↓ | 0.80 |
| CD3 (cells/ul) | 1251.8 (72.05%) | 4037.6 (66.99%) | 3180.0 (74.88%)↑ | 5693.56 (68.86%) | 945.7 (38.13%)↓ | 1452.3 (78.73%) |
| CD4 (cells/ul) | 935.0 (53.82%)↑ | 2758.5 (45.77%)↑ | 2489.6 (58.62%)↑ | 3919.0 (45.25%)↑ | 628.4 (25.34%)↓ | 1034.72 (56.09%) |
| CD4 Naive (%) | 58.87 | NA | NA | 74.20 | 51.80 | 85.30 |
| CD4 CM (%) | 34.85 | NA | NA | 23.40 | 45.60 | 14.30 |
| CD4 EM (%) | 6.21 ↑ | NA | NA | 2.25 | 2.60 | 0.4↓ |
| CD4 TEMRA (%) | 0.07 | NA | NA | 0.15 | 0.00 | 0.00 |
| CD8 (cells/ul) | 245.7 (14.14%) ↓ | 1177.6 (19.54%)↓ | 618.6 (14.57%)↓ | 1634.0 (18.87%) | 247.92 (10%)↑ | 280.49 (15.21%) |
| CD8 Naive (%) | 81.64 | NA | NA | 55.08 | 50.70 | 89.70 |
| CD8 CM (%) | 16.18 | NA | NA | 15.29 | 22.10 | 9.80 |
| CD8 EM (%) | 1.77 | NA | NA | 3.37 | 19.90 ↑ | 0.20 |
| CD8 TEMRA (%) | 0.42 ↓ | NA | NA | 26.26↑ | 7.20 | 0.30 |
| DNT (%) | 7.61 | NA | NA | 3.42 | 6.60 | 4.70 |
| γδ T (%) | 5.87 | NA | NA | 2.49↓ | 4.10 ↓ | 3.8↓ |
| CD16CD56 (cells/ul) | 118.7 (6.83%) | 242.3 (4.02%) | 533.4 (12.56%) | 877.41 (10.13%) | 199.4 (8.04%)↓ | 69.44 (3.76%) |
| IgG (g/L) | 53.00↑ | 9.40↑ | 21.80↑ | 13.56↑ | 19.40 ↑ | 1.00 ↓ |
| IgM (g/L) | 1.89 | 0.32↓ | 2.35↑ | 1.06 | 0.85 | 0.58 ↓ |
| IgA (g/L) | 0.60 | 0.09↓ | 1.21↑ | 0.70 | 0.84↑ | 0.02 ↓ |
| IgE (KU/L) | 49.46 | 16.12 | 142.11↑ | 548.00↑ | 18.14 | 9.81 |
| The reference of immunoglobulin: | ||||||
| 1-3m | 4-6m | 12-36m | ||||
| IgG (g/L) | 2.75-7.50 | 3.7-8.3 | 5.52-11.46 | |||
| IgM (g/L) | 0.05-0.60 | 0.14-0.5 | 0.06-0.74 | |||
| IgA (g/L) | 0.10-0.70 | 0.33-1.25 | 0.6-2.12 | |||
| IgE (KU/L) | <100 | <100 | <100 | |||
WBC, white blood count; ALC, absolute lymphocyte count; ANC, absolute neutrophil count; HB, haemoglobin; CM, central memory; EM, effector memory; TEMRA, terminal effector memory cytotoxic T cells; DNT, TCR αβ+ CD4 and CD8 double-negative T cell; NA, not available.
The percentage and numbers of lymphocyte subsets in the peripheral blood reference to the literature (Ding et al., 2018). ↑: higher than the normal value; ↓: lower than the normal value.