TABLE 4.

Ongoing clinical trials aiming to evaluate nutritional senotherapeutics on immunosenescence, cellular and humoral components, and markers of inflammation and oxidative stress in aged individuals.

Trial number	Nutritional senotherapeutics	Type of study	Intervention	Outcomes	Situation
NCT04994561	Resveratrol + quercetin + fisetin	Phase 1	1,500 mg glucosamine + 600 mg nicotinamide riboside and + 500 mg trans-resveratrol, for 50 weeks	Senescent cell-cycle arrest (MMP-9 measurement)	Not yet recruiting
NCT03675724, AFFIRM-LITE	Quercetin	Phase 2	Fisetin 20 mg/kg/day, orally for 2 consecutive days	Inflammatory markers	Recruiting
NCT05234203	Quercetin + rutin + luteolin + hesperidin	prospective, interventional, single-arm, open-label pilot study	2 capsules of HTB Rejuvenate® (600 mg of quercetin, rutin, luteolin and hesperidin per serving), twice a day for 90 days	Numbers of T-cell subsets and granulocytes	Not yet recruiting

MMP, matrix metallopeptidase.