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. 2022 Sep 8;13:964274. doi: 10.3389/fimmu.2022.964274

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Copyright © 2022 Grivas, Grigoriou, Malissovas, Sentis, Filia, Flouda, Katsimpri, Verginis and Boumpas

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Longitudinal immunophenotypic and transcriptomic analysis in Responders and Non-Responders. (A) Frequencies of immune cell populations in R and NR (myeloid subsets–up, lymphoid subsets–down) at baseline (0-), 1- and 6-month time points. Results are demonstrated as mean with SD. Statistical significance was obtained by two-way ANOVA test. (B) Schematic diagram of the molecular changes over the course of the follow-up period. Venn diagram (left) represents the DEGs between baseline (0-) and 6-month in R and NR, respectively. The bar plots (right) show the corresponding changes in molecular pathways in NR (up) and R (down). (C) Venn diagram representing DEGs between R vs. NR at baseline (0-), 1- and 6-month after treatment initiation. (D) Dot plot representing pathway analysis of DEGs from R vs. NR at 1-month time point after treatment initiation based on g:Profiler database. R, Responders; NR, Non-Responders; DEGs, Differentially expressed genes. *p ≤ 0.05.