Table 3.
Expression of co-stimulatory and activation molecules on B cells during antigen presentation.
| Receptor | Ligand | Function |
|---|---|---|
| CD80/86 | CD28 and CTLA4 | T cell activation and survival (CD28), inhibitory regulation of activated T cells (CTLA4) |
| CD83 | CD83L | Prolonged expansion of CD8 T cells |
| CD278L (ICOSL) | CD278 (ICOS) | Stimulation and proliferation of T cells |
| CD134L (OX40L) | CD134 (OX40) | Stimulation and promotion of IgG response |
| CD137L (4-1BBL) | CD137 (4-1BB) | Stimulation of effector T cells |
| CD40/CD40L | CD40L/CD40 | Activation, maturation, differentiation, proliferation, isotype switching, survival, cytokine production, memory response development |
| CD22 | N-linked oligosaccharides | Adhesion and BCR signaling modulation |
| CD81 | No natural ligands known yet | Credited towards adhesion and T cell-dependent B cell activation |
| CD11a-CD18/CD54(LFA1/ICAM1) | CD54/CD11a-CD18(ICAM1/LFA1) | Cell adhesion and enhanced activation & antigen presentation |
| CD72 | CD100 | Enhanced antigen presentation, development of B1b cells and production of high affinity IgG response |