TABLE 2.

Multivariable cox regression analysis of predictors of major limb amputation

	Univariable analysis		Multivariable analysis
	Crude HR (95% CI)	P value	Adjusted HR (95% CI)	P value
Wound group (reference: DM)	—	—	—	—
PAD group	2.88 (1.97‐4.21)	<.001***	2.47 (1.65‐3.70)	<.001***
DM‐PAD group	2.20 (1.73‐2.81)	<.001***	2.01 (1.53‐2.65)	<.001***
Age (above 70 years old)	1.76 (1.42‐2.19)	<.001***	1.44 (1.15‐1.81)	<.01**
Ischaemic heart disease	2.08 (1.70‐2.55)	<.001***	1.48 (1.18‐1.84)	<.001***
Renal function (reference: normal)	—	—	—	—
Chronic kidney disease	1.89 (1.45‐2.47)	<.001***	1.37 (1.04‐1.82)	.03*
End stage renal failure	2.54 (1.92‐3.36)	<.001***	1.96 (1.45‐2.65)	<.001***
Wound debridement	0.51 (0.37‐0.72)	<.001***	0.66 (0.47‐0.94)	.02*
Minor amputation	0.67 (0.51‐0.87)	<.01**	0.77 (0.58‐1.01)	.06
Revascularization	1.09 (0.88‐1.35)	.43	0.70 (0.54‐0.89)	<.01**

Note: All variables that were included in the multivariable regressions are displayed in the table.

Abbreviations: CI, confidence interval; DM, diabetes; HR, hazard ratio; PAD, peripheral artery disease.

^* P ≤ .05; **P ≤ .01; ***P ≤ .001.