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. 2022 Sep 8;10:989602. doi: 10.3389/fbioe.2022.989602

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Copyright © 2022 Wang, Luo, Lin, Liu and Gu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epigallocatechin-3-gallate selenium nanoparticles (EGCG-Se NP) can protect PC12 cells from H₂O₂-induced damage. (A) H₂O₂-induced damage effect of PC12 cells. (B) EGCG-Se NP increased PC12 cell viability under 500 μm H₂O₂-induced oxidative damage in a dose-dependent manner. (C) Live/dead staining of PC12 cells under different conditions. Scale bar = 20 μm. (D) Dichlorofluorescein (DCF) diacetate staining to detect intracellular reactive oxygen species in PC12 cells. PBS, phosphate-buffered saline; PI, propidium iodide.