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. 2022 Sep 8;13:875091. doi: 10.3389/fmicb.2022.875091

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Copyright © 2022 Ai, Li, Shi, Zhang, Ding, Zhu and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bone resorption was decreased following antibiotic treatment. Numbers of bacterial colonies in oral cavities of mice under (A) aerobic and (B) anaerobic conditions. (C) The linear distance of CEJ-ABC after antibiotic treatment of mice. (D) Representative sagittal 3D images viewed from the buccal side and palatal side of the maxillary molars using Micro-CT, scar bar, 1mm. The mRNA expression levels of IL-1β (E) and TNF-α (F). Data represent 3 independent experiments (n = 6). ** P <0.01, **** P <0.0001.