Table 3.
Intensity of angiopoietin-2 staining (expressed as optical density [OD]) in primary tumors of recurrent and non-recurrent cases of the training and validation cohorts, and in recurrent tumors occurring in transplanted livers, and metastasis of both training and validation cohorts.
| Modena’s training cohort (n = 140) | Bologna’s validation cohort (n = 60) | |||||
|---|---|---|---|---|---|---|
| Recurrent group (n=68) | Non-recurrent group (n=68) | p-value | Recurrent group (n=30) | Non-recurrent group (n=30) | p-value | |
| Primary tumor | ||||||
| Endothelial (T) | 0.435 ± 0.05 | 0.350 ± 0.06 | <0.001 | 0.445 ± 0.01 | 0.400 ± 0.01 | 0.001 |
| Hepatocyte (T) | 0.308 ± 0.07 | 0.306 ± 0.09 | 0.768 | 0.398 ± 0.01 | 0.355 ± 0.04 | 0.098 |
| Hepatocyte (NT) | 0.410 ± 0.05 | 0.409 ± 0.05 | 0.612 | 0.441 ± 0.02 | 0.450 ± 0.02 | 0.432 |
| Recurrent hepatic tumor (n = 12) | ||||||
| Endothelial (T) | 0.528 ± 0.060 | – | – | – | ||
| Hepatocyte (T) | 0.552 ± 0.143 | – | – | – | ||
| Hepatocyte (NT) | 0.560 ± 0.097 | – | – | – | ||
| Extrahepatic metastasis (n = 9) | ||||||
| Lung (n = 4) | ||||||
| Endothelial | 0.645 ± 0.11 | – | 0.579 ± 0.02 | – | ||
| Parenchymal | 0.652 ± 0.14 | – | 0.572 ± 0.03 | – | ||
| Bone (n = 2) | ||||||
| Endothelial | 0.576 ± 0.056 | – | ||||
| Parenchymal | 0.606 ± 0.042 | – | ||||
| Lymph node (n = 3) | ||||||
| Endothelial | 0.790 ± 0.005 | – | ||||
| Parenchymal | 0.749 ± 0.006 | – | ||||
T, Tumor.
NT, Non-tumor.