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. 2022 Sep 8;12:987491. doi: 10.3389/fonc.2022.987491

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Copyright © 2022 Fan, Hou, Zhang, Zeng, Zhang, Zhang, Meng and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Imaging capability of NIR-II probe on blood vessels and tumors, and effect of photothermal therapy. (A) Probe IR-820 imaging of cerebral blood vessels in mice at different tissue depths (scale bar: 100 μm) (50); (B) High resolution imaging of tumor vessels at magnification and gaussian fitting curve of vessel cross section (scale bar: 2 mm) (29); (C–E) NIR-II fluorescence imaging and fluorescence intensity of mouse tumors at different time points (31); (D–F) NIR-II photoacoustic imaging and photoacoustic intensity of mouse tumors at different time points (26); (G) Tumor temperature changes at different time points under NIR laser irradiation (18); (H) Tumor photos and volume changes after photothermal treatment under different conditions, from top to bottom: 1) saline; 2) saline + laser; 3) TSSI NPs; 4) TSSI NPs + laser (18).