Table 3.
The characteristic profiles of PTA for photothermal treatment.
| Study | In vitro photothermal capacity | η (%) | Administration | Conditions of PTT | V0 (mm3) | Times (h) | Days (d) | △T (°C) | Tmax (°C) | Effect |
| Zhang 2021 (7) | 100 μg/ml, 1064 nm, 6 min△T=28°C | 45.7 | NR | NR | NR | NR | 21 | 20.2 | 50.2 | – |
| Dai 2021 (8) | NR, 1064 nm, 5 min,△T=45.4°C | 40.92 | 800 μg/ml | 1064 nm, 1.0 W/cm2, 10 min | NR | 24 | 15 | 21.5 | 50 | ↑ |
| Li 2020 (9) | 5 μg/ml, 808 nm, 10 min,△T=15.8°C | 43.99 | 3.5 mg/kg | 808 nm, 0.96 W/cm2, 10 min | NR | 12 | 16 | 18.1 | 49.1 | – |
| Wang 2019 (10) | 200 μg/ml, 808 nm, 5 min,△T=26.6°C | 32.32 | 1 mg/mL 200 μl | 808 nm, 1.5 W/cm2, 5 min | NR | NR | 14 | NR | NR | ↓ |
| Zheng 2021 (14) | 400 μg/ml, 1064 nm, 5min, △T=34°C | 41.41 | 20 mg/kg | 1064 nm, 1.0 W/cm2,5 min | 80 | 12 | 10 | 17.5 | NR | – |
| Zheng 2020 (15) | NR | NR | 20 mg/kg | 808 nm, 1.0 W/cm2, 5 min | 100 | 8 | 15 | 22.5 | 58.5 | ↓ |
| Zheng 2020 (16) | 600 μg/ml, 808 nm, 5 min, △T=36.9°C | 31.60 | 15 mg/kg | 808 nm, 1.0 W/cm2, 5 min | 100 | 6 | 20 | 17.5 | NR | – |
| Zhao 2020 (17) | NR | 36.50 | 100 μM 200 μl | 808 nm, 1.0 W/cm2, 10 min | 20 | 4 | 21 | 21.7 | NR | – |
| Zhang 2020 (18) | 100×10-6 m, 660 nm, 5 min,△T=28°C | 46 | NR | 660 nm, 0.3 W/cm2, 5 min | NR | 12 | 15 | 17.5 | 54.8 | – |
| Zhang 2020 (19) | 125 μg/ml, 1064 nm, 5min,△T=50°C | 33.4 | 2 mg/ml 100 μl | 1064 nm, 1.0 W/cm2, 5 min | NR | 24 | 15 | NR | NR | ↑ |
| Zhang 2019 (20) | 25 μg/ml, 1064 nm, 400 s,△T=44.5°C | 60 | 1 mg/ml 100 μl | 1064 nm, 1.0W/cm2, 5 min | NR | 10 | 15 | 45 | 75.2 | ↑ |
| Yin 2019 (21) | 0.8 mg/ml, 1064 nm, 6 min,△T=59.5°C | 30.53 | NR | 1064 nm, 1.0 W/cm2, 5 min | 100 | 6 | 14 | 26.2 | 58.2 | – |
| Yang 2020 (22) | 100 μg/ml, 980 nm, 500 s,△T=27.3°C | 38 | 500 μg/kg 80 μl | 980 nm, 0.72W/cm2, 10 min | 100 | 1 | 14 | 24 | 58 | ↓ |
| Xie 2021 (23) | 0.25 mg/ml, 808 nm, 10 min,△T=73°C | 75.60 | NR | 808 nm, 1.0 W/cm2, 4 min | 80 | 24 | 14 | 18.5 | 50 | ↑ |
| Wang 2019 (24) | 600 μg/ml,808 nm, 10 min,△T=23°C | 50.50 | 0.5 mg/ml | 808 nm, 1.0 W/cm2, 10 min | 90 | NR | 13 | NR | 42 | ↓ |
| Sun 2021 (25) | 0.10 mg/ml, 1064 nm, 5min,△T=44.8°C | 44.43 | 2 mg/ml 150 μl | 1064 nm, 1.0 W/cm2, 5 min | NR | NR | 15 | 23.5 | 56 | ↓ |
| Sun 2020 (26) | 200 μg/ml, 808 nm, 5 min,△T=30.8°C | NR | 800 μg/ml 200 μl | 808 nm, 1.0 W/cm2, 5 min | 100 | 8 | 16 | 25 | 59.2 | – |
| Shi 2018 (27) | NR,10 min,△T=32°C | 27.80 | NR | 785 nm, 1.66 W/cm2, 5 min | NR | 2 | 15 | 30.9 | 60.9 | – |
| Li 2021 (28) | 50 μg/ml, 808 nm, 8 min,△T=58°C | 52.80 | 1 mg/ml 200 μl | 808 nm, 1.0 W/cm2, 10 min | 100 | 12 | 14 | 27 | NR | – |
| Li 2019 (29) | 0.2 mg/ml, 808 nm, 10 min,△T=34°C | 40.18 | 0.2 mg/ml 0.2 ml | 808 nm, 10 min | NR | NR | 12 | NR | NR | – |
| Li 2019 (30) | 25 μg/ml, 808m, 5 min,△T=29.8°C | 42.30 | NR | 808 nm, 0.65 W/cm2, 10 min | 150 | 1 | 21 | 20.3 | 51.8 | – |
| Li 2021 (31) | 1 mg/ml, 808 nm, 5 min,△T=47°C | 43.70 | 4 mg/mL 200 μl | 808 nm, 1.0 W/cm2, 5 min | 80 | 24 | 15 | 31.5 | NR | – |
| Li 2019 (32) | 2 mg/ml, 808 nm, 10 min,△T=60°C | 48 | 1 mg/ml | 808 nm, 1.0 W/cm2, 10 min | NR | 24 | 21 | 28 | 60 | – |
| Li 2021 (33) | 2 mg/ml, 808 nm, 5 min,△T=45.7°C | 39.42 | 10 mg/ml 200 μl | 808 nm, 0.3 W/cm2, 10 min | 100 | 12 | 14 | 21 | 56 | – |
| Hu 2019 (34) | 500 μg/ml, 808 nm, 10 min,△T=41°C | 26 | 1 mg/mL 150 μl | 808 nm, 1.0 W/cm2, 10 min | 80 | 24 | 16 | 25 | 58.5 | ↑ |
| Dai 2021 (35) | 80 μg/ml, 1064 nm, 5 min,△T=45.8°C | 39.24 | NR | 1064 nm, 1.0 W/cm2, 10 min | NR | 24 | 14 | 18 | NR | ↑ |
| Chen 2021 (36) | 40 μg/ml, 1064 nm, 400 s,△T=25°C | 55.10 | 2 mg/mL 100 ul | 1064 nm, 1.0 W/cm2, 5 min | 100 | 24 | 15 | 20.7 | 53.2 | ↑ |
| Jia 2021 (37) | 400 μg/ml, 1064 nm, 5 min,△T=34°C | NR | 20 mg/kg | 1064 nm, 1.0 W/cm2, 5 min | 100 | 12 | 10 | NR | NR | – |
| Qian 2021 (38) | 20 μg/ml, 915 nm, 5 min,△T=24.2°C | 35.50 | 8 mg/kg 150 μl | 915 nm, 1.0 W/cm2, 10 min | 100 | 8 | 15 | 21.7 | 48 | – |
| Guan 2021 (39) | 20 μg/ml, 808 nm, 5 min,△T=30°C | 12.91 | 20 μg/ml 200 μl | 808 nm, 1.0 W/cm2, 5 min | 500 | 24 | 14 | 16.9 | 50.1 | – |
| Xia 2020 (40) | 100 μg/ml, 660 nm, 10 min,△T=26°C | 23 | 2 mg/ml 100 μl | 660 nm, 0.3 W/cm2, 10 min | 100 | 20 | 14 | NR | 50 | ↑ |
| Xu 2020 (41) | 100 μg/ml, 730 nm, 10 min,△T=45°C | 50.00 | NR | 730 nm, 1.0 W/cm2, 10 min | NR | 24 | 14 | NR | 54 | ↑ |
| Zhu 2020 (42) | 80 μM, 808 nm, 10 min,△T=62°C | NR | NR | 808 nm, 1.0 W/cm2, 10 min | 50 | 24 | 16 | 18.2 | 53.7 | ↑ |
| Yao 2020 (43) | 1 mg/ml, 915 nm, 5 min,△T=41.2°C | 25.60 | 5 mg/kg | 915 nm, 0.5 W/cm2, 5 min | NR | 12 | 14 | 25.9 | 59.1 | – |
| Wang 2019 (44) | 0.1 mg/ml, 915 nm, 6 min,△T=40°C | 58.20 | 0.25 mg/mL 50 μl | 915 nm, 0.5 W/cm2, 10 min | 120 | 6 | 15 | 48 | 68 | ↑ |
| Meng 2018 (45) | 100 μg/ml, 808 nm, 5 min,△T=37°C | 20.20 | 40 μg/mL 200 μl | 980 nm, 0.1W/cm2, 2 min | 100 | 14 | 30 | 30 | 57 | – |
| Zheng 2021 (46) | 400 μg/ml, 1064 nm, 5 min,△T=36°C | NR | 15 mg/kg | 1064 nm, 1.0 W/cm2, 5 min | 75 | 12 | 12 | 17.89 | 51.9 | – |
| Huang 2020 (47) | 1 mg/ml, 1064 nm, 5 min,△T=35°C | NR | 2 mg/mL 100 μl | 1064 nm, 1.0 W/cm2, 5 min | 100 | 12 | 15 | 24.5 | 52 | ↑ |
| Zhou 2020 (48) | 64 uM, 808 nm, 12 min,△T=30.5°C | 18 | 400 μg/ml 200 μl | 808 nm, 1.5 W/cm2, 8 min | 800 | 12 | 14 | 34.8 | 67.8 | ↓ |
| Yang 2017 (49) | 1.0 mM, 808 nm, 5 min,△T=35°C | 35.0 | 50.0 umol/kg | 785 nm, 1.5 W/cm2, 5 min | 60 | 24 | 30 | 19.0 | NR | – |
| Feng 2019 (50) | 500 μg/ml, 793 nm, 3 min,△T=70.5°C | 32.74 | 2 mg/ml 100 μl | 793 nm, 2.0 W/cm2, 10 min | 120 | 48 | 16 | 24.7 | 55.4 | ↑ |
| Zhao 2019 (51) | 600 μg/ml, 808 nm, 6 min,△T=45°C | 21 | 150 μg/ml 100 μl | 808 nm, 2.5 W/cm2, 10min | 100 | NR | 18 | 61.2 | 61.2 | ↑ |
↑, tumor volume increases; ↓, tumor reduced in size but did not disappear completely; -, complete tumor ablation; η, photothermal conversion efficiency; △T, tumor temperature changes after laser irradiation; Days, treatment cycle; NR, not report; Times, the time at which the NIR laser irradiation began after the probe was given; Tmax, maximum temperature of tumor after laser irradiation; V0, the initial volume of tumor.