Table 3.
Human disease homologs in the DmSP3
| OMIM phenotype | N |
|---|---|
| Autism, Susceptibility To; AUTS20, AUTSX1, AUTSX2 | 27∗ |
| Ciliary Dyskinesia, Primary; CILD40, CILD3, CILD7 | 25∗ |
| Spermatogenic Failure; SPGF39, SPGF45, SPGF46 | 24∗ |
| Myopathy; CFTD, MFM2, Fatal Infantile Hypertonic, Alpha-B Crystallin-Related | 24∗ |
| Hypertension, Essential | 23 |
| Type 2 Diabetes Mellitus; T2D | 21 |
| Asperger Syndrome, X-Linked, Susceptibility To; ASPGX1, ASPGX2 | 18∗ |
| Cataract, Multiple Types; CTRCT16, CTRCT9 | 16∗ |
| Ichthyosis, Congenital, Autosomal Recessive; ARCI4A, ARCI4B | 16∗ |
| 46, XY Sex Reversal 8; SRXY8 | 12 |
| Colorectal Cancer; CRC | 11 |
| Encephalopathy, Familial, With Neuroserpin Inclusion Bodies; FENIB | 11 |
| Ghosal Hematodiaphyseal Dysplasia; GHDD | 10 |
| Plasminogen Activator Inhibitor-1 Deficiency | 10 |
| Vitamin D-Dependent Rickets, Type 3; VDDR3 | 10 |
| Deafness, Autosomal Recessive 91; DFNB91 | 9 |
| Leukemia, Acute Myeloid; AML | 9 |
| Maturity-Onset Diabetes of The Young, Type 8, With Exocrine Dysfunction; MODY8 | 9 |
| Pseudoxanthoma Elasticum; PXE | 9 |
| Cardiomyopathy, Dilated, 1II; CMD1II | 8 |
| Charcot-Marie-Tooth Disease, Axonal, Type 2F; CMT2F | 8 |
| Neuronopathy, Distal Hereditary Motor, Type IIB; HMN2B | 8 |
| Surfactant Metabolism Dysfunction, Pulmonary, 3; SMDP3 | 8 |
Most common human disease phenotypes from the Online Mendelian Inheritance in Man database (OMIM.org) associated with D. melanogaster genes found in the DmSP3. N = number of D. melanogaster genes associated with each phenotype. Similar disease phenotypes (marked with an asterisk) have been grouped. Complete list of disease associations can be found in supplemental Table S15.