Table 3. Mean Genetic Liability as Assessed by Family Genetic Risk Scores for Major Depression and Bipolar Disorder in Cases With and Without Psychosisa.
| MD genetic liability, mean z score (95% CI) | BD genetic liability, mean z score (95% CI) | |
|---|---|---|
| MD (nonpsychotic) | 0.28 (0.28-0.29) | 0.09 (0.08-0.09) |
| MD (psychotic) | 0.27 (0.23-0.30) | 0.20 (0.17-0.24) |
| P value (equality of means) | .36 | <.001 |
| BD (nonpsychotic) | 0.34 (0.33-0.35) | 0.59 (0.57-0.60) |
| BD (psychotic) | 0.24 (0.15-0.33) | 0.82 (0.67-0.97) |
| P value (equality of means) | .04 | .003 |
Abbreviations: BD, bipolar disorder; MD, major depression.
a
Means adjusted for year of birth, sex, and primary care registration.