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. 2022 Sep 6;145(11):4097–4107. doi: 10.1093/brain/awac321

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Relationship between serum brain injury biomarkers and autoantibody profiles. (A and B) Correlation between number of IgG hits and serum GFAP and NfL concentrations at the subacute time point. (C) Correlation between number of IgG hits and serum NfL concentrations at the convalescent time point. (D) Correlation between number of IgM hits and serum total tau concentrations at the convalescent time point. (E) Comparison of convalescent serum brain injury biomarker concentrations between patients with high IgM responses (>3 IgM hits Z > 3) versus those with low IgM responses (<3 IgM hits Z > 3). Two-group unpaired comparisons are by Mann-Whitney U-test, correlations are by Spearman’s rank.