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. 2022 Sep 8;13:974364. doi: 10.3389/fimmu.2022.974364

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Copyright © 2022 Ghaemi, Roshani Asl, Zargaran, Ahmadi, Hashimi, Abdolalipour, Bathaeian and Miri

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IgG titers of mice immunized with different combinations of RBD and nucleocapsid proteins were determined by ELISA from sera collected on the two and nine weeks after last immunization. Data are expressed as means ± SD of three mice per group and difference among individual groups is determined by One way ANOVA and shown as ***for P < 0.001 and ns for a nonstatistical difference. Compared to different formulations or control groups, saponin-adjuvanted RBD/N vaccine significantly induced the highest level of endpoint total IgG and IgG2a isotype.