Table 3.

Relationship of kynurenine and indole pathway metabolites with subclinical markers of CVD

		Aorta calcium score		Coronary calcium score		Agatston CT score		CIMT		LVMI		PWV		FMD
Metabolitesa		r	P-value	r	P-value	r	P-value	r	P-value	r	P-value	r	P-value	r	P-value
	TRP	−0.23	.03	−0.04	.71	<0.01	.99	0.02	.76	−0.1	.17	−0.15	.02	−0.02	.77
Kynurenine pathway	KYN	0.00	.97	0.19	.08	0.18	.04	0.11	.13	0.00	.96	−0.01	.91	0.62	.41
	KTR	0.06	.59	0.21	.05	0.19	.03	0.12	.12	0.02	.74	0.02	.73	0.08	.33
	HK	0.07	.51	0.09	.42	0.03	.70	0.12	.10	0.07	.35	0.04	.48	0.05	.48
	KA	0.03	.79	0.22	.05	0.18	.04	0.07	.34	0.11	.13	0.01	.87	0.06	.44
	AA	0.28	<.01	0.35	<.01	0.20	.02	0.14	.06	0.23	<.01	0.19	<.01	0.01	.87
	HAA	0.17	.12	0.30	<.01	0.27	<.01	0.17	.02	0.05	.47	0.03	.58	0.04	.62
	QA	0.18	.10	0.32	<.01	0.22	.01	0.22	<.01	0.16	.03	0.09	.16	0.09	.22
Indole pathway	IS	−0.06	.62	0.20	.07	0.11	.22	−0.07	.33	0.13	.07	−0.03	.64	−0.01	.91
	IA	−0.01	.91	0.12	.27	0.08	.34	0.03	.65	0.11	.10	−0.02	.72	−0.05	.49

TRP, tryptophan; KYN, kynurenine; KTR, kynurenine: tryptophan ratio; KA, kynurenic acid; AA, anthranilic acid; HAA, hydroxyanthranilic acid; QA, quinolinic acid; IS, indoxyl sulfate; IA, indole-3-acetate. Correlation coefficients (r) and corresponding raw P-values are given; significant values are given in italics. P-values <.05 by the false discovery rate are given in italics and bold.

^aRepresents log-transformed metabolites.