Table 5.

Cox proportional hazards model for time to new CV event by significant serum metabolites

	Model 1		Model 2		Model 3		Model 4		Model 5		Model 6
Model Covariates	Metabolite only		Metabolite, age, gender, race, prior CVD history		Metabolite, age, prior CVD history, eGFR, UPCR		Metabolite, age, prior CVD history, CRP, serum albumin		Metabolite, age, prior CVD history, serum albumin, SBP		Metabolite, age, prior CVD history, serum albumin, DM
Metabolites	HR	P-value	HR	P-value	HR	P-value	HR	P-value	HR	P-value	HR	P-value
	(95% CI)		(95% CI)		(95% CI)		(95% CI)		(95% CI)		(95% CI)
TRP	0.38	.07	0.30	.03	0.40	.1	0.21	.21	0.46	.16	0.49	.2
	(0.14–1.07)		(0.10–0.90)		(0.13–1.18)		(0.16–1.50)		(0.15–1.38)		(0.16–1.47)
AA	1.02	.02	1.01	.07	1.02	.06	1.02	.03	1.02	.03	1.01	.07
	(1.00–1.03)		(1.00–1.03)		(1.00–1.03)		(1.00–1.03)		(1.00–1.03)		(1.00–1.03)
QA	1.28	.01	1.26	.03	1.27	.05	1.31	.01	1.3	.01	1.27	.03
	(1.05–1.55)		(1.02–1.55)		(1.00–1.61)		(1.06–1.61)		(1.05–1.60)		(1.03–1.56)

CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; UPCR, urine protein to creatinine ratio; CRP, C-reactive protein; SBP, systolic blood pressure; DM, diabetes mellitus; CI, confidence interval

TRP, tryptophan; AA, anthranilic acid; QA, quinolinic acid. HRs, 95% CIs and P-values are displayed. Statistically significant (P < .05) HRs and P-values are given in bold.