Table 2.
Linear mixed effect models for eGFR during the follow-up period
| Male (n = 3563) | Female (n = 2023) | |||||
|---|---|---|---|---|---|---|
| Fixed-effect coefficient estimates (95% CI) | SE | P | Fixed-effect coefficient estimates (95% CI) | SE | P | |
| Model 1a | ||||||
| Follow-up year | −1.320 (−2.277, −0.826) | 0.366 | <.001 | −1.248 (−2.103, −0.307) | 0.437 | .004 |
| LDL-C at baseline | −0.022 (−0.036, −0.002) | 0.009 | .011 | −0.031 (−0.052, −0.002) | 0.013 | .015 |
| Interaction (follow-up year and LDL-C at baseline) | −0.001 (−0.002, −0.000) | 0.000 | .036 | 0.001 (−0.000, 0.002) | 0.001 | .238 |
| (AIC = 153 492) | (AIC = 93 982) | |||||
| Model 2a | ||||||
| Follow-up year | −1.444 (−2.489, −1.016) | 0.368 | <.001 | −1.320 (−2.218, −0.428) | 0.435 | .002 |
| HDL-C at baseline | 0.011 (−0.037, 0.039) | 0.020 | .549 | 0.006 (−0.046, 0.044) | 0.023 | .798 |
| Interaction (follow-up year and HDL-C at baseline) | 0.004 (0.001, 0.006) | 0.001 | <.001 | 0.000 (−0.002, 0.002) | 0.001 | .733 |
| (AIC = 155 186) | (AIC = 93 985) | |||||
| Model 3a | ||||||
| Follow-up year | −1.300 (−2.221, −0.800) | 0.362 | <.001 | −1.263 (−2.127, −0.371) | 0.436 | .003 |
| TC at baseline | −0.002 (−0.032, −0.000) | 0.001 | .031 | −0.021 (−0.041, 0.003) | 0.012 | .071 |
| Interaction (follow-up year and TC at baseline) | −0.000 (−0.001, 0.001) | 0.000 | .799 | 0.001 (−.0001, 0.002) | 0.001 | .267 |
| (AIC = 155 199) | (AIC = 93 985) | |||||
| Model 4a | ||||||
| Follow-up year | −1.328 (−2.235, −0.811) | 0.369 | <.001 | −1.368 (−2.245, −0.480) | 0.445 | .002 |
| Log TG at baseline | −0.235 (−1.071, 1.069) | 0.542 | .665 | 0.252 (−1.170, 2.061) | 0.814 | .756 |
| Interaction (follow-up year and LogTG at baseline) | 0.019 (−0.039, 0.075) | 0.029 | .506 | 0.027 (−0.060, 0.122) | 0.046 | .551 |
| (AIC = 155 187) | (AIC = 93 970) | |||||
| Model 5a | ||||||
| Follow-up year | −1.329 (−2.167, −0.387) | 0.369 | <.001 | −1.294 (−2.167, −0.387) | 0.437 | .003 |
| Log TG/HDL-C at baseline | −0.212 (−0.892, 1.665) | 0.426 | .619 | 0.141 (−0.892, 1.665) | 0.644 | .827 |
| Interaction (follow-up year and LogTG/HDL-C at baseline) | −0.017 (−0.057, 0.087) | 0.369 | .461 | 0.010 (−0.057, 0.871) | 0.036 | .788 |
| (AIC = 155 188) | (AIC = 93 972) | |||||
aThe models were adjusted for age, body mass index, systolic blood pressure, smoking habit, hemoglobin, albumin, uric acid, fasting plasma glucose, hematuria and proteinuria at baseline. Hematuria and proteinuria (1+ or more) were evaluated by the dipstick method.
eGFR, estimated glomerular filtration rate; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglycerides. AIC, Akaike's information criterion; CI, confidence interval; SE, standard error.