Fig. 4.

Mutational spectra. Mutational signatures detected in tumour and matched morphologically normal tissue from prostate cancer patients and normal tissue from men without prostate cancer. The mutational spectra of each sample, as defined by the triplets of nucleotides around each SNV, were deconvoluted into mutational signatures (SigProfiler [41]) using the set of signatures defined by Alexandrov et al. [47]. The colour of the first row indicates patient when there is more than a normal-tumour (N-T) pair analysed. Six patients had more than two samples analysed and one patient had only a morphologically normal sample without a matched tumour