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. 2022 Sep 22;21:183. doi: 10.1186/s12943-022-01644-3

Fig. 5.

Fig. 5

Tumours show a distinct mutation profile to normal tissue. A The difference between the number of single nucleotide variants (SNVs) detected in normal tissue compared to tumour tissue. Where multiple samples of either type were present the median number was used. B The distribution of the number of SNVs detected in morphologically normal tissue, tumour tissue with low CNAs (percentage genome altered (PGA) < 6%) and tumour tissue with high CNAs (PGA > 6%). Data from these last two categories came from Wedge et al. [52]