Correlation between the combined panels of serum AAb levels and OST of CMT dogs. CMT dogs (n = 90) were dichotomized by a combination of (A) TYMS-AAbHigh and AGR2-AAbLow (denoted T-AAbHigh/A-AAbLow), (B) IGFBP5-AAbHigh and AGR2-AAbLow (denoted I-AAbHigh/A-AAbLow), (C) TYMS-AAbHigh and IGFBP5-AAbHigh groups (denoted T-AAbHigh/I-AAbLow), and (D) TYMS-AAbHigh, IGFBP5-AAbHigh, and AGR2-AAbLow (denoted T-AAbHigh/I-AAbHigh/A-AAbLow), respectively. OST of CMT dogs was compared between the dichotomous groups by using Kaplan-Meier analysis. Statistical significance was determined by the log-ranked test.