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Nrf2 downstream antioxidant products and Nrf2/NOX4 pathway. Various Nrf2 activators can effectively promote Nrf2 entry into the nucleus and lead to increased expression of its downstream antioxidant products, such asHO−1and SOD, which can further eliminate potential damage to DNA, RNA, proteins, and lipid peroxidation caused by mitochondrial-derived and NOX4-derived ROS.
