Figure 2.

Treatment with HRW at 1T or 2T inhibited the anxiety-like behaviors associated with neuropathic pain. At day 28 after surgery, the number of entries into the open arms (A) and the percentage (%) of time spent in them (B) after 4 or 7 consecutive days of treatment with VEH, HRW 2T or 1T are represented. Sham-operated mice treated with VEH, HRW 2T or 1T are also displayed. For each test, * indicates significant differences vs. sham-operated mice treated with VEH or HRW at 1T or 2T, + vs. CCI-HRW 1T treated mice and $ vs. CCI-HRW 2T treated mice (p < 0.05, one-way ANOVA followed by Bonferroni test). Mean values ± SEM (n = 8 animals per group).