Figure 4.

Reversion of the antinociceptive actions of HRW by the co-administration with HO-1 or NQO1 inhibitors and a K_ATP channels blocker during 4 consecutive days in the ipsilateral paws of CCI mice. The effects of the repetitive co-treatment of VEH or HRW with SnPP, dicoumarol (Dc) or glibenclamide (Glb) administered at 2T from days 25 to 28 after surgery, on the mechanical allodynia (A), thermal hyperalgesia (B) and thermal allodynia (C) induced by CCI are represented. Sham-operated mice are also displayed. In all figures, for each treatment and day analyzed, * indicates significant differences vs. their respective sham-operated treated animals, + vs. CCI-VEH-treated animals and # vs. CCI–HRW–VEH-treated animals (p < 0.05, one-way ANOVA followed by the Bonferroni test). Mean values ± SEM (n = 6 animals per group).