Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Structure of p53 protein showing the different domains and hot spots (red stars) mutations occurring in human cancer. The 393 amino-acid p53 protein is depicted from the amino-terminus (1) to the carboxy-terminus (393) with boundaries for various domains shaded with different colors: transactivation domain (TAD1/2), proline-rich domain (PRD), DNA-binding domain (DBD), nuclear localization signal (NLS), tetramerization domain (TD), C-terminal domain (CTD).
