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Pathogenic NOX-regulated redox signaling circuitry in cardiac myocytes. Depiction of major pathological redox-sensitive signaling effectors and pathways regulated by NOX2 and NOX4 in cardiomyocytes. CaMKII, calcium/calmodulin-dependent protein kinase II; HDAC4, histone deacetylase 4; MEF2, myocyte enhancer factor 2; NFAT, nuclear factor of activated T cells; NFκB, nuclear factor kappa B; ROS, reactive oxygen species.
