Table 2.
(a) LD50 Challenge | |||||||||
Survivability (%) | days post-administration | ||||||||
1 | 3 | 7 | 15 | 28 | 40 | 50 | 60 | ||
1st trial | Bacteriophage | 70 | 80 | 50 | 30 | 40 | 50 | 50 | 40 |
PLGA/alginate | 90 | 90 | 80 | 70 | 60 | 50 | 50 | 50 | |
2nd trial | Bacteriophage | 80 | 60 | 60 | 50 | 50 | 40 | 50 | 40 |
PLGA/alginate | 90 | 80 | 90 | 80 | 70 | 50 | 40 | 50 | |
(b) LD100 challenge | |||||||||
Survivability (%) | days post-administration | ||||||||
1 | 3 | 7 | 15 | 28 | 40 | 50 | 60 | ||
1st trial | Bacteriophage | 80 | 70 | 10 | 10 | 10 | 10 | ND a | ND |
PLGA/alginate | 90 | 80 | 80 | 60 | 40 | 0 | ND | ND | |
2nd trial | Bacteriophage | 80 | 10 | 0 | 0 | 10 | 0 | ND | ND |
PLGA/alginate | 90 | 90 | 70 | 70 | 30 | 0 | ND | ND |