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. 2022 Sep 17;11(9):1264. doi: 10.3390/antibiotics11091264

Table 2.

The extended prophylactic effect of bacteriophages with or without encapsulation (n = 10). Challenge with LD50 (a), and LD100 (b). The survival rate was observed for 7 days. a ND: not done.

(a) LD50 Challenge
Survivability (%) days post-administration
1 3 7 15 28 40 50 60
1st trial Bacteriophage 70 80 50 30 40 50 50 40
PLGA/alginate 90 90 80 70 60 50 50 50
2nd trial Bacteriophage 80 60 60 50 50 40 50 40
PLGA/alginate 90 80 90 80 70 50 40 50
(b) LD100 challenge
Survivability (%) days post-administration
1 3 7 15 28 40 50 60
1st trial Bacteriophage 80 70 10 10 10 10 ND a ND
PLGA/alginate 90 80 80 60 40 0 ND ND
2nd trial Bacteriophage 80 10 0 0 10 0 ND ND
PLGA/alginate 90 90 70 70 30 0 ND ND