Table 3.
Effect of diosmin and/ or trolox on antioxidant defense and oxidative stress markers in the serum of CFA-induced arthritic animals.
| Groups | LPO (nmole MDA/100 mL/hr) | % Change | GSH (nmole/100 mL) | % Change | GST (U/mL) | % Change | SOD (U/mL) | % Change | CAT (U/mL) × 102 | % Change |
|---|---|---|---|---|---|---|---|---|---|---|
| Normal | 0.7 ± 0.47 a | - | 13.2 ± 1.65 b | - | 147.3 ± 7.94 c | - | 4.4 ± 0.27 c | - | 2.00 ± 0.12 b | - |
| Arthritic | 2.1 ± 0.10 c | 200 | 6.2 ± 0.50 a | −53 | 77.1 ± 3.76 a | −48 | 1.0 ± 0.09 a | −77 | 0.50 ± 0.07 a | −75 |
| Arthritic treated with Diosmin | 1.3 ± 0.12 b | −38 | 11.5 ± 0.83 b | 86 | 109.9 ± 4.67 b | 43 | 2.5 ± 0.15 b | 150 | 1.50 ± 0.09 b | 200 |
| Arthritic treated with Trolox | 1.4 ± 0.07 b | −33 | 10.3 ± 0.75 b | 66 | 115.1 ± 13.31 b | 49 | 3.1 ± 0.31 b | 210 | 1.70 ± 0.35 b | 240 |
| Arthritic treated with Diosmin and Trolox | 1.3 ± 0.02 b | −38 | 12.5 ± 1.05 b | 102 | 108.6 ± 8.91 b | 41 | 2.9 ± 0.31 b | 190 | 1.65 ± 0.06 b | 230 |
Data are expressed as mean ± standard error. Each group has a total of six individuals. In the same column, means with the same superscript symbol(s) are not statistically significant. Comparisons of the arthritic group with the normal and arthritic treatment groups with the arthritic group yielded percentage changes (% change).