TABLE 2.
Bacterial and candidal infections among solid organ transplant recipients within 3 months posttransplantation
| Infection typea | Recipients with negative donor cultures (N 88) |
Recipients with positive, non-MDRO, donor cultures (N 477) |
Recipients with MDRO on donor culture (N 93) |
p value |
|---|---|---|---|---|
| Any bacterial or candidal infection | 34 (39%) | 210 (44%) | 45 (48%) | .42 |
| Donor-derived infection | N/Ab | 24 (5%) | 7 (8%) | .33 |
| Infection type | ||||
| Lower respiratory tract infection | 14 (16%) | 104 (22%) | 23 (25%) | .33 |
| Genitourinary infection (UTI, pyelonephritis) | 15 (17%) | 69 (15%) | 20 (22%) | .22 |
| Surgical site infection | 10 (11%) | 43 (9%) | 6 (6%) | .51 |
| Bloodstream infection | 8 (9%) | 33 (7%) | 8 (9%) | .70 |
| Intra-abdominal infection | 4 (5%) | 30 (6%) | 1 (1%) | .10 |
| Skin or soft tissue infection | 7 (8%) | 27 (6%) | 3 (3%) | .42 |
| Clostridioides difficile infection | 4 (5%) | 22 (5%) | 3 (3%) | .91 |
| Etiologic organismc | ||||
| Candida spp | 11 (13%) | 52 (11%) | 11 (12%) | .89 |
| Coagulase-negative Staphylococci | 9 (10%) | 53 (11%) | 5 (5%) | .25 |
| Enterobacterales spp | 19 (22%) | 103 (22%) | 26 (28%) | .40 |
| Enterococcus spp | 10 (11%) | 48 (10%) | 8 (9%) | .83 |
| Pseudomonas spp | 5 (6%) | 48 (10%) | 8 (9%) | .42 |
| Staphylococcus aureus | 6 (7%) | 48 (10%) | 10 (11%) | .63 |
| Stenotrophomonas spp | 1 (1%) | 7 (1%) | 2 (2%) | .87 |
| Streptococcus spp | 1 (1%) | 14 (3%) | 2 (2%) | .79 |
| MDROs | ||||
| Any MDROd | 10 (11%) | 65 (14%) | 18 (19%) | .25 |
| MRSA | 1 (1%) | 16 (3%) | 6 (6%) | .16 |
| VRE | 6 (7%) | 19 (4%) | 7 (8%) | .23 |
| ESC-R Enterobacterales | 5 (6%) | 31 (7%) | 7 (8%) | .88 |
| CRE | 0 (0%) | 7 (1%) | 2 (2%) | .48 |
| MDR-Pseudomonas | 0 (0%) | 10 (2%) | 2 (2%) | .57 |
Abbreviations: CRE, carbapenem-resistant Enterobacterales; ESC-R, extended-spectrum cephalosporin-resistant; MDR, multidrug-resistant; MDRO, multidrug-resistant organism; MRSA, methicillin-resistant S. aureus; spp, species; UTI, urinary tract infection; VRE, vancomycin-resistant Enterococcus.
Data are presented as numbers (percentages) except where noted.
Solid organ transplant recipients whose donors did not have any positive cultures could not have a donor-derived infection, since it is defined by identifying the same organism on donor and recipient cultures.
Etiologic organism identified on recipient culture within 3 months posttransplant.
MDROs included MRSA, VRE, ESC-R Enterobacterales, CRE, MDR-Pseudomonas, and MDR-Acinetobacter.