Figure 1.

CETP expression in macrophages decreases mitochondrial oxidant production. Oxidant production in resting resident (A–C) and thioglycolate-elicited (D–I) peritoneal macrophages from human CETP transgenic and non-transgenic mice (Non-Tg). (A) Mitochondrial superoxide anion production; (B) H₂O₂ release curves; (C) H₂O₂ release rates (curve slopes from B); (D) global oxidant production; (E) total cell superoxide; (F) mitochondrial superoxide anion; (G) total H₂O₂; (H) mitochondrial H₂O₂ and (I) non-mitochondrial H₂O₂ release rates. Non-mitochondrial H₂O₂ contribution was determined in cells treated with carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP) (1 µM) and mitochondrial derived H₂O₂ was calculated as (total - non-mitochondrial H₂O₂). * p < 0.05.