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. 2022 Aug 31;11(9):1734. doi: 10.3390/antiox11091734

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CETP expression in macrophages increases mitochondrial network elongation and the expression of fusion-related genes. Mitochondrial network morphology and gene expression were determined in thioglycolate-elicited peritoneal macrophages from human CETP-Tg and non-transgenic (Non-Tg) mice. (A) Representative images (60× magnification) showing mitochondria stained with MitoTracker (red) and nuclei stained with Hoechst 33342 (blue). (B) The aspect ratio represents the degree of mitochondrial elongation and (C) the form factor represents the extent of network branching degree. (D) mRNA expression of the fusion genes Mitofusin-2 (MFN-2), MFN-1, and OPA-1, and the fission genes dynamin-related protein 1 (DRP-1) and mitochondrial fission 1 protein (FIS-1). * p < 0.05.