Figure 4.

Glucose tolerance is unchanged and postprandial insulin levels are decreased in chow-fed mice with adipocyte-specific LAMA4 deletion. Male Lama4^fl/fl and Lama4^AKO mice were provided a chow diet from weaning until 24 weeks of age. (a) Intraperitoneal glucose tolerance tests were performed after 18 weeks on diet (n = 15–16 mice per genotype after a 4-h fast). Serum (b) insulin levels and (c) leptin levels in fed mice (n = 6 per genotype) were measured by ELISA. (d) Representative images of H&E-stained liver sections (n = 5–7 per group), demonstrate no differences in hepatic lipid accumulation. Scale bars = 250 μm.