Figure 6.

Glucose tolerance is improved, and postprandial insulin levels are unchanged in HFD-fed mice with adipocyte-specific LAMA4 deletion. Male Lama4^fl/fl and Lama4^AKO mice were provided HFD from 6–26 weeks of age. (a) Intraperitoneal glucose tolerance tests were performed after 18 weeks on diet (n = 15–16 mice per genotype after a 4-h fast). (b) The area under curve calculated from (a). (c) Insulin levels and (d) leptin levels in serum from fed mice (n = 6 per genotype) were measured by ELISA. (e) Representative images of H&E-stained liver sections (n = 5–7 per group). * p < 0.05 between genotypes. Scale bars = 250 μm.