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. 2022 Aug 25;10(9):2077. doi: 10.3390/biomedicines10092077

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Volcano plots depicting differential eWAT expression patterns across diet (chow or HFD) or genotype (Lama4^fl/fl mice or Lama4^AKO) comparisons. (a) High-fat vs. chow diet comparison in Lama4^fl/fl mice; (b) High-fat vs. chow diet comparison in Lama4^AKO mice; (c) Lama4^fl/fl mice vs. Lama4^AKO mice on a high-fat diet; (d) Lama4^fl/fl mice vs. Lama4^AKO mice on chow diet. RD = chow diet, HFD = high-fat diet, WT = Lama4^fl/fl and KO = Lama4^AKO. The top 20 differentially expressed genes are annotated in each volcano plot, with full gene names appearing in Appendix B. Dashed lines represent the significance cutoffs for identifying genes as significantly regulated.

Volcano plots depicting differential eWAT expression patterns across diet (chow or HFD) or genotype (Lama4^fl/fl mice or Lama4^AKO) comparisons. (a) High-fat vs. chow diet comparison in Lama4^fl/fl mice; (b) High-fat vs. chow diet comparison in Lama4^AKO mice; (c) Lama4^fl/fl mice vs. Lama4^AKO mice on a high-fat diet; (d) Lama4^fl/fl mice vs. Lama4^AKO mice on chow diet. RD = chow diet, HFD = high-fat diet, WT = Lama4^fl/fl and KO = Lama4^AKO. The top 20 differentially expressed genes are annotated in each volcano plot, with full gene names appearing in Appendix B. Dashed lines represent the significance cutoffs for identifying genes as significantly regulated.