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. 2022 Aug 24;11(9):1642. doi: 10.3390/antiox11091642

Figure 2.

Figure 2

SEL-12/presenilin loss does not induce the mitochondrial unfolded response. (A) Representative images (scale bar = 0.1 mm) of GFP fluorescence intensity hsp-6p::GFP transgenic animals as a reporter for UPRmt. (B,C) Quantification of GFP fluorescence intensity in hsp-6p::GFP (B) or in hsp-60p::GFP (C) transgenic animals as reporters for the UPRmt. Paraquat (PQ) was used to induce mitochondrial ROS as a positive control. (D) Quantification of GFP fluorescence intensity in hsp-4p::GFP transgenic animals as a reporter for UPRER. sca-1(RNAi) was used as a positive control to knock down expression of the sarco-endoplasmic reticulum calcium ATPase (SERCA) to induce an ER stress response. (n ≥ 20). ns p > 0.05, **** p < 0.0001 using one-way (B,C) with Kruskal-Wallis multiple comparison test. Comparisons are made to wild type unless otherwise indicated. Error bars indicate mean +/− SEM.