Activation of SKN-1 improves soft touch response and resistance to oxidative stress in sel-12 mutants. (A) Response to anterior and posterior soft touch in sel-12 mutants and sel-12 mutants carrying activating mutations in skn-1. (n = 20) (B) Paraquat survival assay in wild type, sel-12 mutants, and animals carrying activating mutations in skn-1 after 24-h exposure to either 50, 100, or 150 mM paraquat (50 animals per strain, performed 3 times). ns p > 0.05, * p < 0.05, *** p < 0.001 using one-way ANOVA with Kruskal-Wallis test (A) or two-way ANOVA with Bonferroni test (B). Error bars indicate mean +/− SEM.