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. 2022 Aug 24;11(9):1642. doi: 10.3390/antiox11091642

Figure 6.

Figure 6

Hyperactivation of mTORC1 is not sufficient to cause neurodegeneration. (A) Western blot of p-RSKS-1/S6k in wild type, nprl-3 and sesn-1 mutants indicating increased mTORC1 activity and (B) quantification of p-RSKS-1/actin in (A). (C) Quantification of response to anterior and posterior soft touch in wild type, sesn-1, nprl-3, and sel-12 mutants. (n = 20). (D) Relative mitochondrial oxidation levels in animals expressing mitochondria targeted roGFP1 in the TRNs. (n ≥ 15). (E) Quantification of frequency of healthy and aberrant ALM neurons present in wild type, sesn-1, nprl-3, and sel-12 mutants. (n ≥ 20). ns p > 0.05, * p < 0.05, ** p < 0.01, *** p < 0.001 using one-way ANOVA with Kruskal-Wallis multiple comparison test. Comparisons are made to wild type unless otherwise indicated. Error bars indicate mean +/− SEM.