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. 2022 Sep 8;11(3):58. doi: 10.3390/antib11030058

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Documentation of IgM and IgG antibodies against HLA class Ib molecules in the sera of male (non-alloimmunized) and female (volunteers). Interestingly, naturally occurring IgM antibodies are more prevalent than IgG for HLA-E (A). In contrast, naturally occurring IgG antibodies are more prevalent than IgM for HLA-F and HLA-G (B,C). Simultaneous prevalence of higher IgM than IgG in HLA-E, HLA-F and HLA-G, suggests that these individuals may be experiencing induction of IgM due to various pathological conditions such as inflammation, injury and other disorders. (A) Anti-HLA-E IgM and IgG; (B) PosiAnti-HLA-F IgM and IgG; (C) Anti-HLA-G IgM and IgG.

Documentation of IgM and IgG antibodies against HLA class Ib molecules in the sera of male (non-alloimmunized) and female (volunteers). Interestingly, naturally occurring IgM antibodies are more prevalent than IgG for HLA-E (A). In contrast, naturally occurring IgG antibodies are more prevalent than IgM for HLA-F and HLA-G (B,C). Simultaneous prevalence of higher IgM than IgG in HLA-E, HLA-F and HLA-G, suggests that these individuals may be experiencing induction of IgM due to various pathological conditions such as inflammation, injury and other disorders. (A) Anti-HLA-E IgM and IgG; (B) PosiAnti-HLA-F IgM and IgG; (C) Anti-HLA-G IgM and IgG.